COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine.
Identifieur interne : 001742 ( Main/Exploration ); précédent : 001741; suivant : 001743COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine.
Auteurs : Francesco Fontana [Italie] ; Gaetano Alfano [Italie] ; Giacomo Mori [Italie] ; Alessio Amurri [Italie] ; Lorenzo Tei [Italie] ; Marco Ballestri [Italie] ; Marco Leonelli [Italie] ; Francesca Facchini [Italie] ; Francesca Damiano [Italie] ; Riccardo Magistroni [Italie] ; Gianni Cappelli [Italie]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Anticorps monoclonaux humanisés (administration et posologie), Antiviraux (administration et posologie), Appréciation des risques (MeSH), Betacoronavirus (MeSH), Comorbidité (MeSH), Défaillance rénale chronique (chirurgie), Défaillance rénale chronique (complications), Humains (MeSH), Hydroxychloroquine (administration et posologie), Immunosuppresseurs (administration et posologie), Infections à coronavirus (complications), Infections à coronavirus (thérapie), Infections à coronavirus (traitement médicamenteux), Mâle (MeSH), Néphrite interstitielle (chirurgie), Néphrite interstitielle (complications), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (thérapie), Résultat thérapeutique (MeSH), Transplantation rénale (MeSH), Ventilation artificielle (MeSH).
- MESH :
- administration et posologie : Anticorps monoclonaux humanisés, Antiviraux, Hydroxychloroquine, Immunosuppresseurs.
- chirurgie : Défaillance rénale chronique, Néphrite interstitielle.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus.
- complications : Adulte d'âge moyen, Appréciation des risques, Betacoronavirus, Comorbidité, Défaillance rénale chronique, Humains, Infections à coronavirus, Mâle, Néphrite interstitielle, Pandémies, Pneumopathie virale, Résultat thérapeutique, Transplantation rénale, Ventilation artificielle.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Humanized (administration & dosage), Antiviral Agents (administration & dosage), Betacoronavirus (MeSH), COVID-19 (MeSH), Comorbidity (MeSH), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Coronavirus Infections (therapy), Humans (MeSH), Hydroxychloroquine (administration & dosage), Immunosuppressive Agents (administration & dosage), Kidney Failure, Chronic (complications), Kidney Failure, Chronic (surgery), Kidney Transplantation (MeSH), Male (MeSH), Middle Aged (MeSH), Nephritis, Interstitial (complications), Nephritis, Interstitial (surgery), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (therapy), Respiration, Artificial (MeSH), Risk Assessment (MeSH), SARS-CoV-2 (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Antiviral Agents, Hydroxychloroquine, Immunosuppressive Agents.
- complications : Coronavirus Infections, Kidney Failure, Chronic, Nephritis, Interstitial, Pneumonia, Viral.
- drug therapy : Coronavirus Infections.
- surgery : Kidney Failure, Chronic, Nephritis, Interstitial.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, COVID-19, Comorbidity, Humans, Kidney Transplantation, Male, Middle Aged, Pandemics, Respiration, Artificial, Risk Assessment, SARS-CoV-2, Treatment Outcome.
Abstract
Coronavirus disease 2019 (COVID-19) pneumonia has been poorly reported in solid organ transplanted patients; prognosis is uncertain and best management unclear. We describe the case of a 61-year-old kidney transplant recipient with several comorbidities who was hospitalized and later received a diagnosis of COVID-19 pneumonia; the infection was successfully managed with the use of hydroxychloroquine and a single administration of tocilizumab, after immunosuppression reduction; the patient did not require mechanical ventilation. During the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, transplant clinicians should be readily informed about new cases of COVID-19 pneumonia in solid organ transplant recipients, with focus on therapeutic strategies employed and their outcome.
DOI: 10.1111/ajt.15935
PubMed: 32324331
PubMed Central: PMC7264495
Affiliations:
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sortKey="Alfano, Gaetano" sort="Alfano, Gaetano" uniqKey="Alfano G" first="Gaetano" last="Alfano">Gaetano Alfano</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Mori, Giacomo" sort="Mori, Giacomo" uniqKey="Mori G" first="Giacomo" last="Mori">Giacomo Mori</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Amurri, Alessio" sort="Amurri, Alessio" uniqKey="Amurri A" first="Alessio" last="Amurri">Alessio Amurri</name><affiliation wicri:level="1"><nlm:affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Tei, Lorenzo" sort="Tei, Lorenzo" uniqKey="Tei L" first="Lorenzo" last="Tei">Lorenzo Tei</name><affiliation wicri:level="1"><nlm:affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Ballestri, Marco" sort="Ballestri, Marco" uniqKey="Ballestri M" first="Marco" last="Ballestri">Marco Ballestri</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Leonelli, Marco" sort="Leonelli, Marco" uniqKey="Leonelli M" first="Marco" last="Leonelli">Marco Leonelli</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Facchini, Francesca" sort="Facchini, Francesca" uniqKey="Facchini F" first="Francesca" last="Facchini">Francesca Facchini</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Damiano, Francesca" sort="Damiano, Francesca" uniqKey="Damiano F" first="Francesca" last="Damiano">Francesca Damiano</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Magistroni, Riccardo" sort="Magistroni, Riccardo" uniqKey="Magistroni R" first="Riccardo" last="Magistroni">Riccardo Magistroni</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Cappelli, Gianni" sort="Cappelli, Gianni" uniqKey="Cappelli G" first="Gianni" last="Cappelli">Gianni Cappelli</name><affiliation wicri:level="1"><nlm:affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal, Humanized (administration & dosage)</term><term>Antiviral Agents (administration & dosage)</term><term>Betacoronavirus (MeSH)</term><term>COVID-19 (MeSH)</term><term>Comorbidity (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (therapy)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (administration & dosage)</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Kidney Failure, Chronic (complications)</term><term>Kidney Failure, Chronic (surgery)</term><term>Kidney Transplantation (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Nephritis, Interstitial (complications)</term><term>Nephritis, Interstitial (surgery)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (therapy)</term><term>Respiration, Artificial (MeSH)</term><term>Risk Assessment (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Anticorps monoclonaux humanisés (administration et posologie)</term><term>Antiviraux (administration et posologie)</term><term>Appréciation des risques (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Comorbidité (MeSH)</term><term>Défaillance rénale chronique (chirurgie)</term><term>Défaillance rénale chronique (complications)</term><term>Humains (MeSH)</term><term>Hydroxychloroquine (administration et posologie)</term><term>Immunosuppresseurs (administration et posologie)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (thérapie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Mâle (MeSH)</term><term>Néphrite interstitielle (chirurgie)</term><term>Néphrite interstitielle (complications)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (thérapie)</term><term>Résultat thérapeutique (MeSH)</term><term>Transplantation rénale (MeSH)</term><term>Ventilation artificielle (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antiviral Agents</term><term>Hydroxychloroquine</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term><term>Antiviraux</term><term>Hydroxychloroquine</term><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" qualifier="chirurgie" xml:lang="fr"><term>Défaillance rénale chronique</term><term>Néphrite interstitielle</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Kidney Failure, Chronic</term><term>Nephritis, Interstitial</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Kidney Failure, Chronic</term><term>Nephritis, Interstitial</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term><term>COVID-19</term><term>Comorbidity</term><term>Humans</term><term>Kidney Transplantation</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Respiration, Artificial</term><term>Risk Assessment</term><term>SARS-CoV-2</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Appréciation des risques</term><term>Betacoronavirus</term><term>Comorbidité</term><term>Défaillance rénale chronique</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Néphrite interstitielle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Résultat thérapeutique</term><term>Transplantation rénale</term><term>Ventilation artificielle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) pneumonia has been poorly reported in solid organ transplanted patients; prognosis is uncertain and best management unclear. We describe the case of a 61-year-old kidney transplant recipient with several comorbidities who was hospitalized and later received a diagnosis of COVID-19 pneumonia; the infection was successfully managed with the use of hydroxychloroquine and a single administration of tocilizumab, after immunosuppression reduction; the patient did not require mechanical ventilation. During the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, transplant clinicians should be readily informed about new cases of COVID-19 pneumonia in solid organ transplant recipients, with focus on therapeutic strategies employed and their outcome.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32324331</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>20</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine.</ArticleTitle><Pagination><MedlinePgn>1902-1906</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.15935</ELocationID><Abstract><AbstractText>Coronavirus disease 2019 (COVID-19) pneumonia has been poorly reported in solid organ transplanted patients; prognosis is uncertain and best management unclear. We describe the case of a 61-year-old kidney transplant recipient with several comorbidities who was hospitalized and later received a diagnosis of COVID-19 pneumonia; the infection was successfully managed with the use of hydroxychloroquine and a single administration of tocilizumab, after immunosuppression reduction; the patient did not require mechanical ventilation. During the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, transplant clinicians should be readily informed about new cases of COVID-19 pneumonia in solid organ transplant recipients, with focus on therapeutic strategies employed and their outcome.</AbstractText><CopyrightInformation>© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fontana</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-0762-0942</Identifier><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alfano</LastName><ForeName>Gaetano</ForeName><Initials>G</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-0591-8622</Identifier><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mori</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amurri</LastName><ForeName>Alessio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tei</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ballestri</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leonelli</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Facchini</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Damiano</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Magistroni</LastName><ForeName>Riccardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cappelli</LastName><ForeName>Gianni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>I031V2H011</RegistryNumber><NameOfSubstance UI="C502936">tocilizumab</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D061067" MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007676" MajorTopicYN="N">Kidney Failure, Chronic</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016030" MajorTopicYN="Y">Kidney Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009395" MajorTopicYN="N">Nephritis, Interstitial</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">clinical research/practice</Keyword><Keyword MajorTopicYN="N">immunosuppressant - fusion proteins and monoclonal antibodies</Keyword><Keyword MajorTopicYN="N">infection and infectious agents - viral</Keyword><Keyword MajorTopicYN="N">infectious disease</Keyword><Keyword MajorTopicYN="N">kidney transplantation/nephrology</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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first="Alessio" last="Amurri">Alessio Amurri</name><name sortKey="Ballestri, Marco" sort="Ballestri, Marco" uniqKey="Ballestri M" first="Marco" last="Ballestri">Marco Ballestri</name><name sortKey="Cappelli, Gianni" sort="Cappelli, Gianni" uniqKey="Cappelli G" first="Gianni" last="Cappelli">Gianni Cappelli</name><name sortKey="Cappelli, Gianni" sort="Cappelli, Gianni" uniqKey="Cappelli G" first="Gianni" last="Cappelli">Gianni Cappelli</name><name sortKey="Damiano, Francesca" sort="Damiano, Francesca" uniqKey="Damiano F" first="Francesca" last="Damiano">Francesca Damiano</name><name sortKey="Facchini, Francesca" sort="Facchini, Francesca" uniqKey="Facchini F" first="Francesca" last="Facchini">Francesca Facchini</name><name sortKey="Leonelli, Marco" sort="Leonelli, Marco" uniqKey="Leonelli M" first="Marco" last="Leonelli">Marco Leonelli</name><name sortKey="Magistroni, Riccardo" sort="Magistroni, Riccardo" uniqKey="Magistroni R" first="Riccardo" last="Magistroni">Riccardo Magistroni</name><name sortKey="Magistroni, Riccardo" sort="Magistroni, Riccardo" uniqKey="Magistroni R" first="Riccardo" last="Magistroni">Riccardo Magistroni</name><name sortKey="Mori, Giacomo" sort="Mori, Giacomo" uniqKey="Mori G" first="Giacomo" last="Mori">Giacomo Mori</name><name sortKey="Tei, Lorenzo" sort="Tei, Lorenzo" uniqKey="Tei L" first="Lorenzo" last="Tei">Lorenzo Tei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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